Methdilazine

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Methdilazine
Methdilazine.svg
Systematic (IUPAC) name
10-[(1-methylpyrrolidin-3-yl) methyl]- 10H-phenothiazine
Clinical data
AHFS/Drugs.com monograph
Identifiers
CAS Number 1982-37-2 YesY
ATC code R06AD04 (WHO)
PubChem CID: 14677
IUPHAR/BPS 7231
DrugBank DB00902 YesY
ChemSpider 14009 YesY
UNII 4Q13LY9Z8X YesY
KEGG D04979 YesY
ChEMBL CHEMBL1200959 N
Chemical data
Formula C18H20N2S
Molecular mass 296.431 g/mol
  • S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4
  • InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 YesY
  • Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.

Synthesis

Methdilazine synthesis:[1] R. F. Feldkamp and Y. H. Wu; Mead Johnson & Company; U.S. Patent 2,945,855 (1960).

See also

References

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The ring-contracted analog, methdilazine, interestingly enough shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.


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  1. ↑ L. W. Marsch and R. Peterson, Arzneimittel Forsch., 9, 715 (1959).
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