Desloratadine
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| Systematic (IUPAC) name | |
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8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine
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| Clinical data | |
| Trade names | Clarinex |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a602002 |
| Licence data | EMA:Link, US FDA:link |
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| Routes of administration |
Oral |
| Pharmacokinetic data | |
| Bioavailability | Rapidly absorbed |
| Protein binding | 85% |
| Metabolism | Hepatic |
| Biological half-life | 27 hours |
| Excretion | 40% as conjugated metabolites into urine Similar amount into the feces |
| Identifiers | |
| CAS Number | 100643-71-8  |
| ATC code | R06AX27 (WHO) |
| PubChem | CID: 124087 |
| IUPHAR/BPS | 7157 |
| DrugBank | DB00967 |
| ChemSpider | 110575 |
| UNII | FVF865388R |
| KEGG | D03693 |
| ChEBI | CHEBI:291342 |
| ChEMBL | CHEMBL1172 |
| Chemical data | |
| Formula | C19H19ClN2 |
| Molecular mass | 310.82 |
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Desloratadine is a tricyclic H1-antihistamine that is used to treat allergies. It is an active metabolite of loratadine.
Use
Desloratadine is used to treat allergic rhinitis and nasal congestion.[1] It is the major metabolite of loratadine and the two drugs are similar in safety and effectiveness.[1]
Side effects
Most common side-effects are fatigue, dry mouth, headache, and gastrointestinal disturbances.[1]
Mechanism of action
Desloratadine is a selective H1-antihistamine which functions as an inverse agonist at the histamine H1 receptor;[2] it is also an antagonist at all subtypes of the muscarinic acetylcholine receptors. It has a long-lasting effect and in moderate and low doses. It exhibits only peripheral activity since it does not readily cross the blood-brain barrier; hence, it does not cause drowsiness because it does not readily enter the central nervous system.[3]
Society and culture
Desloratadine is available in many dosage forms and under many trade names worldwide.[4]
