Telenzepine

Telenzepine

Systematic (IUPAC) name
1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one
Identifiers
CAS Number	80880-90-6
ATC code	None
PubChem	CID: 5387
ChemSpider	5194
UNII	0990EG3K10 Y
ChEMBL	CHEMBL253978
Chemical data
Formula	C19H22N4O2S
Molecular mass	370.47 g/mol
SMILES CC1=C2C(=CS1)C(=O)NC3=CC=CC=C3N2C(=O)CN4CCN(CC4)C

Telenzepine is a thienobenzodiazepine acting as selective M₁ antimuscarinic. It is used in the treatment of peptic ulcers. Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis; in neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active as the (–)-isomer at muscarinic receptors in the rat cerebal cortex.

See also

• Pirenzepine