Pargyline

Pargyline
Systematic (IUPAC) name
	N-benzyl-N-methylprop-2-yn-1-amine
Clinical data
MedlinePlus	a682088
Identifiers
CAS Number	555-57-7
ATC code	C02KC01 (WHO) C02LL01
PubChem	CID: 4688
IUPHAR/BPS	7262
DrugBank	DB01626
ChemSpider	4526
UNII	9MV14S8G3E
ChEMBL	CHEMBL673
Chemical data
Formula	C11H13N
Molecular mass	159.23 g/mol
	SMILES C#CCN(C)Cc1ccccc1 ;
	InChI InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3 ; Key:DPWPWRLQFGFJFI-UHFFFAOYSA-N ;
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Pargyline (Eutonyl) is an irreversible selective monoamine oxidase (MAO) inhibitor drug (IC₅₀ for MAO-A is 0.01152 µmol/L and for MAO-B is 0.00820 µmol/L)^[1] ^[2] It was brought to market in the US and the UK by Abbott in 1963 as "Eutonyl" as an antidepressant, and was one of several other MAO inhibitors brought to market in the 1960s, along with nialamide, isocarboxazid, phenelzine, and tranylcypromine.^[3]^:146^[4]^:60^[5]

As of 2007 the drug was discontinued^[6] and as of 2014 there were no generic versions in the US.^[7]

References

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↑ Edward Shorter, A historical dictionary of psychiatry. Oxford University Press, Inc 2005. ISBN 0195176685
↑ William M. Wardell and Louis Lasagna. Regulation Drug Development (Evaluative Studies 21) American Enterprise Institute (1975) ISBN 0844731676
↑ Council on Drugs New Drugs and Developments in Therapeutics: Pargyline Hydrochloride (Eutonyl) JAMA. 1963;184(11):887. doi:10.1001/jama.1963.03700240079013.
↑ W. Steven Pray Interactions Between Nonprescription Products and Psychotropic Medications US Pharmacist. 2007;32(11):12-15.
↑ FDA Eutonyl in the Drugs@FDA Database Accessed July 19, 2014