CX-516

CX-516

Systematic (IUPAC) name
6-(piperidin-1-ylcarbonyl)quinoxaline
Pharmacokinetic data
Biological half-life	45 minutes
Identifiers
CAS Number	154235-83-3 Y
PubChem	CID: 148184
IUPHAR/BPS	4165
ChemSpider	130635 Y
UNII	Z5QU38B4V9 Y
KEGG	C13675 Y
ChEMBL	CHEMBL136800 Y
Chemical data
Formula	C14H15N3O
Molecular mass	241.289 g/mol
SMILES O=C(c2cc1nccnc1cc2)N3CCCCC3
InChI InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2 Y Key:ANDGGVOPIJEHOF-UHFFFAOYSA-N Y
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CX-516 is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator and is being developed by a collaboration of Cortex and Shire and Servier. It was researched as a treatment for Alzheimer's disease under the brand name Ampalex, and was also being examined as a treatment for ADHD.

CX-516 was the first ampakine compound developed by Cortex and while it showed good in vitro activity and positive results in animal tests, the human trials proved disappointing due mainly to low potency and short half-life. However, CX-516 is still widely used in animal research into the ampakine drugs and is the standard reference compound that newer, more potent drugs of this class such as farampator and CX-717 are compared to.

See also

• Ampakine
• Nootropic

References

• CX-516 therapy in Alzheimer's disease, schizophrenia and mild cognitive impairment