Traxoprodil

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Traxoprodil
File:Traxoprodil.svg
Systematic (IUPAC) name
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol
Identifiers
CAS Number 134234-12-1 N
189894-57-3 (methanesulphonate)
ATC code none
PubChem CID: 219101
IUPHAR/BPS 4163
ChemSpider 189919 YesY
UNII UTC046R5HM YesY
KEGG D06204 N
ChEMBL CHEMBL17350 YesY
Synonyms Traxoprodil, CP-101,606
Chemical data
Formula C20H25NO3
Molecular mass 327.416 g/mol
  • c2cc(O)ccc2C(O)C(C)N3CCC(O)(CC3)c1ccccc1
  • InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1 YesY
  • Key:QEMSVZNTSXPFJA-HNAYVOBHSA-N YesY
 NYesY (what is this?)  (verify)

Traxoprodil (CP-101,606) is a drug developed by Pfizer which acts as an NMDA antagonist, selective for the NR2B subunit.[1][2] It has neuroprotective,[3] analgesic,[4] and anti-Parkinsonian effects in animal studies.[5][6] Traxoprodil has been researched in humans as a potential treatment to lessen the damage to the brain after stroke,[7][8][9][10] but results from clinical trials showed only modest benefit.[11]The drug was found to cause EKG abnormalities (QT prolongation) and its clinical development was stopped.[12] More recent animal studies have suggested traxoprodil may exhibit rapid-acting antidepressant effects similar to those of ketamine,[13] although there is some evidence for similar psychoactive side effects and abuse potential at higher doses,[14] which might limit clinical acceptance of traxoprodil for this application.

See also

References

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