L-AP4

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L-AP4
200px
Systematic (IUPAC) name
(2S)-2-amino-4-phosphonobutanoic acid
Identifiers
CAS Number 23052-81-5 YesY
PubChem CID: 179394
IUPHAR/BPS 1410
ChemSpider 156157 N
Chemical data
Formula C4H10NO5P
Molecular mass 183.099 g/mol
  • C(CP(=O)(O)O)[C@@H](C(=O)O)N
  • InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1 N
  • Key:DDOQBQRIEWHWBT-VKHMYHEASA-N N
 NYesY (what is this?)  (verify)

L-2-amino-4-phosphonobutyric acid (or L-AP4) is a drug used in scientific research, which acts as a group-selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,[1] but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.[2][3][4][5]

References

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