Aceglutamide

Aceglutamide

Names
IUPAC name 2-(Acetylamino)-glutaramidic acid
Other names KW-110; α-N-Acetylglutamine
Identifiers
CAS Number	2490-97-3 S Y
ChemSpider	23836 Y 392045 R Y 158492 S Y
DrugBank	DB04167 Y
EC Number	219-647-7
Jmol 3D model	Interactive image Interactive image
KEGG	D07063 Y
MeSH	aceglutamide
PubChem	25561 444019 R 182230 S
UNII	01J18G9G97 Y
InChI InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13) Y Key: KSMRODHGGIIXDV-UHFFFAOYSA-N Y
SMILES Cc(:[o]):[nH]C(CCc(:[nH2]):[o])c(:[o]):[oH] CC(=O)NC(CCC(N)=O)C(O)=O
Properties
Chemical formula	C7H12N2O4
Molar mass	188.18 g·mol−1
Appearance	White crystals
Melting point	197 °C (387 °F; 470 K)
Related compounds
Related alkanoic acids	N-Acetylaspartic acid N-Acetylglutamic acid Citrulline Pivagabine
Related compounds	Bromisoval Carbromal
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Aceglutamide (INN, JAN) (brand name Neuramina), or aceglutamide aluminum (JAN, USAN) (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain. Aceglutamide functions as a prodrug to glutamine with improved potency and stability. Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition. The drug has shown neuroprotective effects in an animal model of cerebral ischemia.