Denopamine

Denopamine
Systematic (IUPAC) name
	4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Number	71771-90-9
ATC code	none
PubChem	CID: 71754
IUPHAR/BPS	534
ChemSpider	64795
UNII	V5F60UPD8P
KEGG	D02614
ChEMBL	CHEMBL493682
Chemical data
Formula	C18H23NO4
Molecular mass	317.37 g/mol
	SMILES O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C ;

Denopamine (INN) is a cardiotonic drug which acts as a Beta-1 adrenergic receptor agonist.^[1] It is used in the treatment of angina^[2] and may also have potential uses in the treatment of congestive heart failure^[3] and for clearing pulmonary oedema.^[4]

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References

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↑ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002;18(7):407-13. PMID 12487507
↑ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. 2006 Apr 4;108(2):281-3. PMID 15913812
↑ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. 1998 Sep;32(3):808-15. doi:10.1016/S0735-1097(98)00314-3 PMID 9741531
↑ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. 2001 Feb;85(2):161-6. doi:10.1254/jjp.85.161 PMID 11286398