POLE2

Polymerase (DNA directed), epsilon 2, accessory subunit
Polymerase (DNA directed), epsilon 2, accessory subunit
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2V6Z
Identifiers
Symbols	POLE2 ; DPE2
External IDs	OMIM: 602670 MGI: 1197514 HomoloGene: 2015 GeneCards: POLE2 Gene
EC number	2.7.7.7
Gene ontology
Molecular function	• DNA binding; • DNA-directed DNA polymerase activity; • protein binding;
Cellular component	• nucleoplasm; • epsilon DNA polymerase complex; • intracellular membrane-bounded organelle;
Biological process	• G1/S transition of mitotic cell cycle; • mitotic cell cycle; • telomere maintenance via recombination; • telomere maintenance; • DNA replication; • DNA-dependent DNA replication; • DNA replication initiation; • DNA repair; • transcription-coupled nucleotide-excision repair; • nucleotide-excision repair; • nucleotide-excision repair, DNA gap filling; • telomere maintenance via semi-conservative replication; • error-prone translesion synthesis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
Species	Human
Entrez	5427
Ensembl	ENSG00000100479
UniProt	P56282
RefSeq (mRNA)	NM_001197330
RefSeq (protein)	NP_001184259
Location (UCSC)	Chr 14:; 49.64 – 49.69 Mb
PubMed search	[1]
	v; t; e;

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.^[1]^[2]^[3]

Interactions

POLE2 has been shown to interact with SAP18.^[4]

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