Sodium–hydrogen antiporter 1

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.[1]

Function

The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.[2]

Interactions

Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II[3] and CHP.[4][5][6] It is also the target of the experimental drug rimeporide, which is being developed for the treatment of Duchenne muscular dystrophy.[7]

References

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Further reading

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  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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