Sarcospan
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| sarcospan | |
|---|---|
| Identifiers | |
| Symbol | SSPN |
| Entrez | 8082 |
| HUGO | 11322 |
| OMIM | 601599 |
| Other data | |
| Locus | Chr. 12 p11.2 |
Sarcospan, discovered by the research group of Kevin Campbell, is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly.[1] Loss of sarcospan expression occurs in patients with Duchenne muscular dystrophy, indicating that dystrophin is required for proper localization of sarcospan.[1] Sarcospan knockout mice exhibit normal muscle structure and function, indicating that sarcospan is not necessary for muscle to develop.[2]
References
- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
External links
- Sarcospan at the US National Library of Medicine Medical Subject Headings (MeSH)
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