Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes[2][3] Some members of this family have been shown to facilitate protein sorting.
Family members
In humans, sorting nexins are transcribed from the following genes:
Genes |
Domain Composition |
N-terminus |
Mid-1 |
Mid-2 |
Mid-3 |
C-terminus |
SNX1, SNX2 |
Sorting_nexin_N |
– |
PX |
– |
BAR[4] (Vps5) |
SNX4, SNX7, SNX8, SNX30 |
– |
– |
PX |
– |
BAR[4] (Vsp5) |
SNX5, SNX6, SNX32 |
– |
– |
PX |
– |
BAR[4] |
SNX9, SNX18, SNX33 |
SH3 |
– |
PX |
– |
BAR[4] (BAR_3_WASP_bdg)[5] |
SNX13, SNX14, SNX19, SNX25 |
PXA[6] |
RGS |
PX |
– |
Nexin_C |
SNX15 |
– |
– |
PX |
– |
MIT[7] |
SNX17, SNX31 |
– |
– |
PX |
RA[8] |
FERM_M[9] |
SNX23 |
kinesin_motor |
SMAD_FHA[10] |
PX |
– |
– |
SNX26 |
– |
– |
PX |
SH3 |
RhoGAP |
SNX27 |
PDZ |
– |
PX |
- |
RA |
SNX28 |
– |
– |
PX |
SH3 |
SH3 |
SNX3, SNX10, SNX11, SNX12, SNX16, SNX20, SNX21, SNX22, SNX24, SNX29 |
– |
– |
PX |
– |
– |
Structure
Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains.
A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus. (The BAR domain of SNXs 1, 2, 4, 7, 8 and 30 is classified by pfam as 'Vps5 C terminal like'.)
An example of a sorting nexin domain structure can be seen here for SNX1:
- NTD – N-terminal domain
- PX domain
- CTD – C-terminal BAR domain
File:Sorting nexin schematic.png
Schematic diagram of the 1D structures of a representative sorting nexin, the sorting nexin 1 (SNX1). NTD = N-terminal SNX domain, PX = PX domain, CTD = C-terminal BAR domain.
References
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- ↑ BAR_3_WASP_bdg: WASP-binding domain of Sorting nexin protein, Pfam PF10456
- ↑ PXA: PXA domain, Pfam PF02194
- ↑ MIT: MIT (microtubule interacting and transport) domain, Pfam PF04212
- ↑ RA: Ras association (RalGDS/AF-6) domain, Pfam PF00788
- ↑ FERM_M: FERM central domain, Pfam PF00373
- ↑ SMAD_FHA: SMAD/FHA domain, IPR008984
External links
Sorting nexins
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SNX-BAR |
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SNX-PX |
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SNX-Other |
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Related articles |
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Index of genetics
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Description |
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Disease |
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