ZM-241,385

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ZM-241,385
200px
Names
IUPAC name
4-(2-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol
Identifiers
139180-30-6 YesY
ChEMBL ChEMBL1628689 N
ChemSpider 153646 N
405
Jmol 3D model Interactive image
PubChem 176407
  • InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) N
    Key: PWTBZOIUWZOPFT-UHFFFAOYSA-N N
  • InChI=1/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
    Key: PWTBZOIUWZOPFT-UHFFFAOYAJ
  • Oc1ccc(CCNc2nc3nc(c4ccco4)nn3c(N)n2)cc1
Properties
C16H15N7O2
Molar mass 337.34 g·mol−1
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

ZM-241,385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.[1]

In animal models, ZM-241,385 has been shown to protect against beta amyloid neurotoxicity and therefore may be useful as a treatment for Alzheimer's disease.[2] ZM-241,385 has also been shown to enhance L-DOPA derived dopamine release and therefore may be useful in the treatment of Parkinson's disease.[3]

References

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External links

ZM 241385 at the US National Library of Medicine Medical Subject Headings (MeSH)



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