Beta-ketoacyl-acyl-carrier-protein synthase I

3-oxoacyl-[acyl-carrier-protein] synthase
Identifiers
EC number	2.3.1.41
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase I (EC 2.3.1.41) is an enzyme that catalyzes the chemical reaction

an acyl-acyl-carrier-protein + malonyl-acyl-carrier-protein $\rightleftharpoons$ a 3-oxoacyl-acyl-carrier-protein + CO₂ + acyl-carrier-protein

Thus, the two substrates of this enzyme are acyl-acyl-carrier-protein and malonyl-acyl-carrier-protein, whereas its 3 products are 3-oxoacyl-acyl-carrier-protein, CO₂, and acyl carrier protein. This enzyme participates in fatty acid biosynthesis. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.

Nomenclature

The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating).

Other names in common use include:

• beta-ketoacyl-ACP synthase I,
• beta-ketoacyl synthetase,
• beta-ketoacyl-ACP synthetase,
• beta-ketoacyl-acyl carrier protein synthetase,
• beta-ketoacyl-[acyl carrier protein] synthase,
• beta-ketoacylsynthase,
• condensing enzyme,
• 3-ketoacyl-acyl carrier protein synthase,
• fatty acid condensing enzyme,
• acyl-malonyl(acyl-carrier-protein)-condensing enzyme,
• acyl-malonyl acyl carrier protein-condensing enzyme,
• beta-ketoacyl acyl carrier protein synthase,
• 3-oxoacyl-[acyl-carrier-protein] synthase,
• 3-oxoacyl:ACP synthase I,
• KASI,
• KAS I,
• FabF1, and
• FabB.

References

• Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.