Lercanidipine

Lercanidipine

Systematic (IUPAC) name
2[(3,3-diphenylpropyl)(methyl)amino]-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
Trade names	Zanidip
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only)
Routes of administration	Oral
Pharmacokinetic data
Bioavailability	~10% (due to first-pass effect)
Protein binding	>98%
Metabolism	CYP3A4
Onset of action	1.5–3 hours
Biological half-life	8–10 hours
Excretion	Urine (50%)
Identifiers
CAS Number	100427-26-7
ATC code	C08CA13 (WHO)
PubChem	CID: 65866
DrugBank	DB00528 Y
ChemSpider	59276 Y
UNII	V7XTJ4R0BH Y
KEGG	D08111 Y
ChEMBL	CHEMBL250270 Y
Chemical data
Formula	C36H41N3O6
Molecular mass	611.727 g/mol
SMILES [O-][N+](=O)c1cccc(c1)C4C(=C(/N\C(=C4\C(=O)OC(C)(C)CN(CCC(c2ccccc2)c3ccccc3)C)C)C)\C(=O)OC
InChI InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3 Y Key:ZDXUKAKRHYTAKV-UHFFFAOYSA-N Y
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Lercanidipine is a calcium channel blocker of the dihydropyridine class,which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. It is sold under various commercial names including Zanidip. This lowers the blood pressure and allows the heart to work more efficiently.

External links

• DDB 31597