Tolibut

Tolibut

Systematic (IUPAC) name
4-Amino-3-(4-methylphenyl)butanoic acid
Identifiers
CAS Number	28311-38-8 28311-37-7 (HCl)
ATC code	None
PubChem	CID: 49344
ChemSpider	44852
Chemical data
Formula	C11H15NO2
Molecular mass	193.2423 g/mol
SMILES CC1=CC=C(C=C1)C(CC(=O)O)CN
InChI InChI=1S/C11H15NO2/c1-8-2-4-9(5-3-8)10(7-12)6-11(13)14/h2-5,10H,6-7,12H2,1H3,(H,13,14) Key:MSZRPURXKHMSFF-UHFFFAOYSA-N

Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) (that is, a GABA analogue) and the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substition. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia, though it may have been. Tolibut probably acts as a GABA_B receptor agonist similarly to phenibut and baclofen.