EMDT

EMDT

Systematic (IUPAC) name
2-(2-ethyl-5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
Identifiers
ATC code	none
PubChem	CID: 6918513
IUPHAR/BPS	12
ChemSpider	5293710 N
Chemical data
Formula	C15H22N2O
Molecular mass	246.347 g/mol
SMILES CCc2nc1ccc(OC)cc1c2CCN(C)C
InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3 N Key:ZEYRDXUWJDGTLD-UHFFFAOYSA-N N
NY (what is this?)  (verify)

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT) is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT₆ receptor agonist, with a K_i of 16 nM, and was one of the first selective agonists developed for this receptor. EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT₆ antagonist SB-399,885. Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.

See also

• EMD-386,088
• ST-1936