SB-742457

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SB-742457
File:SB-742457-structure.png
Systematic (IUPAC) name
3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline
Clinical data
Legal status
  • Investigational
Routes of
administration		 Oral
Identifiers
CAS Number 607742-69-8 YesY
ATC code none
PubChem CID: 11256720
ChemSpider 9431746 N
UNII 2IOB2M82HY YesY
ChEMBL CHEMBL1083390 N
Chemical data
Formula C19H19N3O2S
Molecular mass 353.44 g/mol
  • C3CNCCN3c1cccc(c1nc4)cc4S(=O)(=O)c2ccccc2
  • InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2 N
  • Key:JJZFWROHYSMCMU-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

SB-742457 (RVT-101[1]) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.[2][3][4][5] It was under development by GlaxoSmithKline for the treatment of Alzheimer's disease and demonstrated some preliminary efficacy in phase II clinical trials;[4][5][6] however, GSK chose not to continue development and sold the rights to Axovant Sciences in December 2014.[7][8]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ 4.0 4.1 Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ 5.0 5.1 Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.[self-published source]
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.



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