JWH-176

JWH-176

Systematic (IUPAC) name
1-([(1E)-3-pentylinden-1-ylidine]methyl)naphthalene
Clinical data
Legal status	Legal
Identifiers
CAS Number	619294-62-1 Y
ChemSpider	29341653
Chemical data
Formula	C25H24
Molecular mass	324.457 g/mol
SMILES CCCCCc(c3)c1ccccc1c3=Cc2cccc4ccccc24
InChI InChI=1S/C25H24/c1-2-3-4-11-21-18-22(25-16-8-7-15-24(21)25)17-20-13-9-12-19-10-5-6-14-23(19)20/h5-10,12-18H,2-4,11H2,1H3/b22-17- Key:FPESBQVTVSBBSE-XLNRJJMWSA-N
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JWH-176 is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB₁ receptor is only 26.0nM, making it more potent than THC itself, however JWH-176 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor. It was discovered by, and named after, Dr. John W. Huffman.

See also

• JWH-175