Org 28312

Org 28312
Systematic (IUPAC) name
	[1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)methanone
Identifiers
CAS Number	1244028-73-6
PubChem	CID: 10069407
ChemSpider	24581999
ChEMBL	CHEMBL1209708
Chemical data
Formula	C24H35N3O2
Molecular mass	397.552 g/mol
	SMILES COc2cccc1c2n(CC4CCCCC4)cc1C(=O)N(CC3C)CC(C)N3C ;
	InChI InChI=1S/C24H35N3O2/c1-17-13-27(14-18(2)25(17)3)24(28)21-16-26(15-19-9-6-5-7-10-19)23-20(21)11-8-12-22(23)29-4/h8,11-12,16-19H,5-7,9-10,13-15H2,1-4H3/t17-,18+ ; Key:DMYGECJTVMCGEP-HDICACEKSA-N ;
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Org 28312 is a drug developed by Organon International which acts as a potent cannabinoid receptor full agonist at both the CB₁ and CB₂ receptors. It was developed with the aim of finding a water-soluble cannabinoid agonist suitable for intravenous use as an analgesic, but did not proceed to human trials, with the related compound Org 28611 chosen instead due to its better penetration into the brain.^[1] The structure-activity relationships of these compounds have subsequently been investigated further leading to the development of a number of more potent analogues, derived by cyclisation around the indole or piperazine rings.^[2]^[3]

References

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