RVD-Hpα
| RVD-Hpα fragment of hemoglobin, alpha 1 | |
|---|---|
| Identifiers | |
| Symbol | HBA1 |
| CAS number | |
| Entrez | 3039 |
| HUGO | 4823 |
| OMIM | 141800 |
| RefSeq | NM_000558 |
| UniProt | P69905 |
| Other data | |
| Locus | Chr. 16 p13.3 |
RVD-Hpα is an endogenous neuropeptide found in human and mammalian brain, which was originally proposed to act as a selective agonist for the CB1 cannabinoid receptor. It is a 12-amino acid polypeptide having the amino acid sequence Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His and is an N-terminal extended form of hemopressin, a 9-AA polypeptide derived from the α1 subunit of hemoglobin which has previously been shown to act as a CB1 inverse agonist.[1] All three polypeptides have been isolated from various mammalian species, with RVD-Hpα being one of the more abundant neuropeptides expressed in mouse brain, and these neuropeptides represent a new avenue for cannabinoid research distinct from the previously known endogenous lipid-derived cannabinoid agonists such as anandamide.[2] Recently it was shown that RVD-Hpα (also called Pepcan-12) is a potent negative allosteric modulator at CB1 receptors, together with other newly described N-terminally extended peptides (pepcans).[3]
| species | RVD-Hpα sequence |
|---|---|
| human | RVDPVNFKLLSH |
| mouse | RVDPVNFKLLSH |
| rat | RVDPVNFKfLSH |
| consensus | RVDPVNFKxLSH |
References
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