ETV6

Transcription factor ETV6 is a protein that in humans is encoded by the ETV6 gene. ETV6 is an oncogene.

Function

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia, congenital fibrosarcoma and more recently an unusual salivary tumor that has been termed "mammary analogue secretory carcinoma of salivary glands."

Interactions

ETV6 has been shown to interact with Grb2, FLI1 and HTATIP. It can form a fusion gene with ABL1 called ETV6/ABL1 (or TEL/ABL under the previous gene names).

Mouse Mutant Alleles for Etv6
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI	Etv6
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse.	Etv6tm1a(KOMP)Wtsi
Example structure of targeted conditional mutant allele for this gene
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Etv6: see Knockout mouse

See also

• TEL-JAK2

External links

• ETV6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Drosophila anterior open - The Interactive Fly

This article incorporates text from the United States National Library of Medicine, which is in the public domain.