PHF1

PHD finger protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E5P, 2M0O, 4HCZ
Identifiers
Symbols	PHF1 ; MTF2L2; PCL1; PHF2; TDRD19C; hPHF1
External IDs	OMIM: 602881 MGI: 98647 HomoloGene: 7567 GeneCards: PHF1 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein binding • zinc ion binding • methylated histone binding Cellular component • nucleus • nucleoplasm • cytoplasm • microtubule organizing center • ESC/E(Z) complex • site of double-strand break Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • cellular response to DNA damage stimulus • gene expression • chromatin modification • regulation of gene expression, epigenetic • negative regulation of gene expression, epigenetic • negative regulation of histone H3-K27 methylation • positive regulation of histone H3-K27 methylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5252	21652
Ensembl	ENSG00000112511	ENSMUSG00000024193
UniProt	O43189	Q9Z1B8
RefSeq (mRNA)	NM_002636	NM_001302397
RefSeq (protein)	NP_002627	NP_001289326
Location (UCSC)	Chr 6: 33.41 – 33.42 Mb	Chr 17: 26.93 – 26.94 Mb
PubMed search	[1]	[2]

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.

External links

• PHF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.