STAT1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.
Function
STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element.[1] In either case, binding of the promoter element leads to an increased expression of ISG (Interferon-Stimulated Genes).
Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.[2]
Interactions
STAT1 has been shown to interact with:
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- BRCA1,[3]
- C-jun,[4]
- CD117,[5]
- CREB-binding protein,[6]
- Calcitriol receptor,[7]
- Epidermal growth factor receptor,[8][9]
- Fanconi anemia, complementation group C,[10][11][12]
- GNB2L1,[13][14]
- IFNAR2,[13][15]
- IRF1,[16]
- ISGF3G[17]
- Interleukin 27 receptor, alpha subunit,[18]
- MCM5,[19][20]
- Mammalian target of rapamycin,[21]
- PIAS1,[22]
- PRKCD,[21]
- PTK2,[23]
- Protein kinase R,[24][25]
- STAT2,[26][27][28]
- STAT3,[9][29][30]
- Src,[8][31] and
- TRADD.[32]
References
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<references />, or <references group="..." />Further reading
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External links
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