Rev-ErbA
From Infogalactic: the planetary knowledge core
| nuclear receptor subfamily 1, group D, member 1 | |
|---|---|
| Identifiers | |
| Symbol | NR1D1 |
| Alt. symbols | ear-1, hRev, Rev-ErbAalpha, THRA1 |
| Entrez | 9572 |
| HUGO | 7962 |
| OMIM | 602408 |
| RefSeq | NM_021724 |
| UniProt | P20393 |
| Other data | |
| Locus | Chr. 17 q11.2 |
| nuclear receptor subfamily 1, group D, member 2 | |
|---|---|
| Identifiers | |
| Symbol | NR1D2 |
| Alt. symbols | BD73, RVR, EAR-1r, HZF2, Hs.37288 |
| Entrez | 9975 |
| HUGO | 7963 |
| OMIM | 602304 |
| RefSeq | XM_001130839 |
| UniProt | Q14995 |
| Other data | |
| Locus | Chr. 3 p24.1 |
The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors. There are two forms of the receptor, alpha and beta, each encoded by a separate gene (NR1D1 and NR1D2 respectively).[1][2]
The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor (TR) gene.[1]
The rev-Erb-α protein is a key regulatory component of the circadian clock.[3][4] In addition, rev-Erb-α appears also to regulate the breakdown of cartilage.[5]
References
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External links
- HZF-2alpha at the US National Library of Medicine Medical Subject Headings (MeSH)
- HZF-2beta at the US National Library of Medicine Medical Subject Headings (MeSH)
- NR1D1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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