TRPC6

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).

Interactions

TRPC6 has been shown to interact with:

• FYN,
• TRPC2, and
• TRPC3.

Ligands

Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin. These compounds are inhibitors of the reuptake of serotonin, norepinephrine ,dopamine, γ-aminobutyric acid, and glutamate, and they exert these effects by binding to and activating TRPC6. Activation of TRPC6 induces the entry of Ca²⁺ and Na⁺ into the cell, which results in the inhibition of reuptake.

External links

• TRPC6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)