TRPM7

Transient receptor potential cation channel, subfamily M, member 7
PDB rendering based on 1ia9.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ia9, 1iah, 1iaj
Identifiers
Symbols	TRPM7 ; ALSPDC; CHAK; CHAK1; LTRPC7; LTrpC-7; TRP-PLIK
External IDs	OMIM: 605692 HomoloGene: 9774 IUPHAR: 499 ChEMBL: 1250412 GeneCards: TRPM7 Gene
EC number	2.7.11.1
Gene ontology Molecular function • actin binding • protein serine/threonine kinase activity • calcium channel activity • ATP binding • myosin binding • metal ion binding Cellular component • ruffle • plasma membrane • integral component of membrane Biological process • cellular magnesium ion homeostasis • calcium-dependent cell-matrix adhesion • actomyosin structure organization • ion transmembrane transport • protein autophosphorylation • transmembrane transport • necroptotic process • calcium ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54822	58800
Ensembl	ENSG00000092439	ENSMUSG00000027365
UniProt	Q96QT4	Q923J1
RefSeq (mRNA)	NM_001301212	NM_001164325
RefSeq (protein)	NP_001288141	NP_001157797
Location (UCSC)	Chr 15: 50.55 – 50.69 Mb	Chr 2: 126.79 – 126.88 Mb
PubMed search	[1]	[2]

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.

Function

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]

Interactions

TRPM7 has been shown to interact with PLCB1 and PLCB2.

Clinical relevance

Defects in this gene have been associated to magnesium deficiency in human microvascular endothelial cells.

See also

• TRPM

External links

• TRPM7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.