TRPM5

Transient receptor potential cation channel, subfamily M, member 5
Identifiers
Symbols	TRPM5 ; LTRPC5; MTR1
External IDs	OMIM: 604600 HomoloGene: 22818 IUPHAR: 497 ChEMBL: 1628468 GeneCards: TRPM5 Gene
Gene ontology Molecular function • ion channel activity • calcium activated cation channel activity • voltage-gated ion channel activity • potassium channel activity • sodium channel activity Cellular component • plasma membrane • integral component of membrane Biological process • ion transmembrane transport • regulation of ion transmembrane transport • sodium ion transmembrane transport • sensory perception of taste • transmembrane transport • calcium ion transmembrane transport • potassium ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29850	56843
Ensembl	ENSG00000070985	ENSMUSG00000009246
UniProt	Q9NZQ8	Q9JJH7
RefSeq (mRNA)	NM_014555	NM_020277
RefSeq (protein)	NP_055370	NP_064673
Location (UCSC)	Chr 11: 2.4 – 2.42 Mb	Chr 7: 143.07 – 143.09 Mb
PubMed search	[1]	[2]

Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.

Function

TRPM5 is a key component of taste transduction in the gustatory system of bitter, sweet and umami tastes being activated by high levels of intracellular calcium. It has also been targeted as a possible contributor to fat taste signaling. The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an action potential.

See also

• TRPM

External links

• TRPM5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• IUPHAR
• HGNC Gene families
• Pfam

This article incorporates text from the United States National Library of Medicine, which is in the public domain.