Adiponectin receptor 1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.[1]
Contents
Structure
Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[1]
Function
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[1][2]
Ligands
Agonists
Peptide
Non-peptide
Antagonists
Peptide
See also
References
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