Corticotropin-releasing hormone receptor 1

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name.[1] In humans, CRF1 is encoded by the CRHR1 gene.[2][3]

Function

The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone receptors, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.[4]

CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.[5]

Evolution

Corticotrophin releasing hormone (CRH) evolved ~500 million years ago in an organism that subsequently gave rise to both chordates and arthropods.[6] The binding site for this was single CRH like receptor. In vertebrates this gene was duplicated leading to the extant CRH1 and CRH2 forms. Additionally four paralogous ligands developed including CRH, urotenin-1/urocortin, urocortin 2 and urocortin 3.

Clinical significance

Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma.[7]

CRF1 triggers cells to release hormones that are linked to stress and anxiety [original reference missing].Hence CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.[8][9]

Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn.[10]

Interactions

Corticotropin-releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone[11][12] and Urocortin.[13]

See also

References

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Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  6. ↑ Lovejoy D, Chang B, Lovejoy N, Del Castillo J (2014) Origin and functional evolution of the corticotrophin-releasing hormone receptors. J Mol Endocrinol
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