AdipoRon
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Systematic (IUPAC) name | |
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2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
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Clinical data | |
Routes of administration |
Oral |
Identifiers | |
CAS Number | 924416-43-3 |
ATC code | None |
PubChem | CID: 16307093 |
ChemSpider | 11029953 |
Chemical data | |
Formula | C27H28N2O3 |
Molecular mass | 428.52282 g/mol |
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AdipoRon is a selective, orally active, synthetic small-molecule agonist of the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) (Kd = 1.8 μM and 3.1 μM, respectively).[1][2] It activates AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in db/db mice (an animal model for type II diabetes and obesity).[1][2] Moreover, AdipoRon has been found to extend the lifespans of db/db mice fed a high-fat diet, as well as improve exercise endurance.[1][2][3] The compound was discovered by Japanese researchers in 2013 via screening of a compound library, and is the first orally active, small-molecule agonist of the adiponectin receptors to be identified.[1][2]
Adiponectin receptor agonists such as AdipoRon have attracted interest as potential therapies for obesity, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and a panoply of other conditions.[1][2] In addition, adiponectin has recently been elucidated to mediate the antidepressant, anxiolytic, and neurogenic effects of physical exercise.[4][5][6] Dysregulation of adiponectin expression has also been implicated in the pathology of mood disorders, anxiety disorders, eating disorders, neurodegenerative disorders, and various other neuropsychiatric disorders.[7] Also, it has been determined that exercise improves insulin resistance via activation of AdipoR1.[8] As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions.[1][2][6][7] Moreover, it has been suggested they could potentially be used as a substitute for exercise to achieve similar physical and mental health benefits.[1][2][6][9]
References
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