Corticorelin

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Corticorelin
Corticorelin.png
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
CAS Number 79804-71-0
ATC code V04CD04 (WHO)
PubChem CID: 16132344
UNII 305OE8862Y YesY
Chemical data
Formula C205H339N59O63S
Molecular mass 4670.31 g/mol
  (verify)

Corticorelin (INN) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).[1]

The corticorelin stimulation test helps to differentiate between the etiologies of adrenocorticotropic hormone (ACTH)-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

  • If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
  • If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of ectopic ACTH syndrome is confirmed.

See also

References

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