Parathyroid hormone receptor

parathyroid hormone 1 receptor
Identifiers
Symbol	PTH1R
Alt. symbols	PTHR, PFE
Entrez	5745
HUGO	9608
OMIM	168468
RefSeq	NM_000316
UniProt	Q03431
Other data
Locus	Chr. 3 p22-p21.1

parathyroid hormone 2 receptor
Identifiers
Symbol	PTH2R
Entrez	5746
HUGO	9609
OMIM	601469
RefSeq	NM_005048
UniProt	P49190
Other data
Locus	Chr. 2 q33

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.

• parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.
• parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.

External links

• Parathyroid Hormone Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)