Melanin-concentrating hormone receptor
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| melanin-concentrating hormone receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | MCHR1 |
| Alt. symbols | GPR24 |
| Entrez | 2847 |
| HUGO | 4479 |
| OMIM | 601751 |
| RefSeq | NM_005297 |
| UniProt | Q99705 |
| Other data | |
| Locus | Chr. 22 q13.3 |
| melanin-concentrating hormone receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | MCHR2 |
| Alt. symbols | GPR145 |
| Entrez | 84539 |
| HUGO | 20867 |
| OMIM | 606111 |
| RefSeq | NM_032503 |
| UniProt | Q969V1 |
| Other data | |
| Locus | Chr. 6 q16 |
Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.
- MCH-R1 is expressed in all mammals.
- MCH-R2 is only found in some primates and carnivores including dogs, ferrets and man.
Clinical significance
Antagonists might be useful in the treatment of obesity[1][2] and anxiety and depression.[3] An agonist might have possible utility as a treatment for osteoporosis[4] and insomnia[5]
Research is ongoing for antagonists affecting MCH receptors R1 and R2.[6][7]
See also
References
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External links
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- melanin-concentrating hormone receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
- MCHR1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- MCHR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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