SB-205,384

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SB-205,384
SB-205384.png
Systematic (IUPAC) name
but-2-ynyl 4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyridine-3-carboxylate
Clinical data
Legal status
  • Investigational New Drug
Identifiers
CAS Number 160296-13-9 YesY
PubChem CID: 197690
Chemical data
Formula C17H18N2O3S
Molecular mass 330.401 g/mol
  • CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N
  (verify)

SB-205,384 is an anxiolytic drug. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.

SB-205,384 is a GABAA positive allosteric modulator, which binds preferentially to α3, α5, and α6 subunit containing subtypes.[1][2] It has a novel mechanism of action, prolonging the duration of GABA-mediated chloride flux but without increasing the intensity of the response, and this may give it an unusual pharmacological profile,[3] with tests showing that it alters the firing of some populations of neurons while leaving others unaffected.[4] Animal studies have shown it to produce both anxiolytic and anti-aggressive effects, but with little sedation or other behavioural changes.[5][6]

References

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