SB-649,868
From Infogalactic: the planetary knowledge core
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Systematic (IUPAC) name | |
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N-([(2S)-1-([5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl)-2-piperidinyl]methyl)-4-benzofurancarboxamide
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Clinical data | |
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Identifiers | |
ATC code | None |
PubChem | CID: 25195495 |
ChemSpider | 25069706 |
ChEMBL | CHEMBL1272307 |
Chemical data | |
Formula | C26H24FN3O3S |
Molecular mass | 477.549 g/mol (free base) |
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SB-649,868 is a dual orexin receptor antagonist in development by GlaxoSmithKline.[1] The drug is currently in phase II development for insomnia.
A phase I study evaluated doses up to 80 mg, resulting in significant improvement in sleep latency without adverse effects.[2]
In randomized, double-blind, placebo-controlled crossover trials, the 10 and 30 mg doses increased sleep time and reduced sleep latency.[3] The subsequent study added a 60 mg dose and observed dose-dependent sleep promotion.[4]
See also
References
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Further reading
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Categories:
- Pages with reference errors
- Chemical articles having calculated molecular weight overwritten
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- Hypnotics
- Sedatives
- Orexin antagonists
- Sedative stubs