Ubenimex
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Names | |
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IUPAC name
(2S)-2-[[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
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Other names
Bestatin; N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
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Identifiers | |
58970-76-6 65391-42-6 (HCl) |
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ChEMBL | ChEMBL29292 ![]() |
ChemSpider | 65145 |
Jmol 3D model | Interactive image |
PubChem | 72172 |
UNII | I0J33N5627 ![]() |
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Properties | |
C16H24N2O4 | |
Molar mass | 308.38 g·mol−1 |
Melting point | 245 °C (473 °F; 518 K) (decomposes) |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B),[2] leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities),[3] alanyl aminopeptidase (aminopeptidase M/N),[4] leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase),[5][6] and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia.[7] It is derived from Streptomyces olivoreticuli.[8] Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds.[citation needed]

See also
References
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External links
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- ↑ N-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl)-L-leucine at Sigma-Aldrich
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- Pages with reference errors
- Chemical articles with multiple CAS Registry Numbers
- Articles without KEGG source
- Pages using collapsible list with both background and text-align in titlestyle
- Articles with unsourced statements from October 2015
- Enkephalinase inhibitors
- Protease inhibitors
- Experimental cancer drugs
- Pharmacology stubs