Cyamemazine

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Cyamemazine
Cyamemazine.svg
Systematic (IUPAC) name
10-(3-dimethylamino-2-methyl-propyl)phenothiazine-2-carbonitrile
Clinical data
Trade names Tercian
AHFS/Drugs.com International Drug Names
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Oral, IM, IV
Pharmacokinetic data
Bioavailability 10-70%
Metabolism Hepatic
Biological half-life 10 hours
Excretion Urine
Identifiers
CAS Number 3546-03-0 YesY
ATC code N05AA06 (WHO)
PubChem CID: 62865
IUPHAR/BPS 84
DrugBank DB09000 N
ChemSpider 56597 YesY
UNII A2JGV5CNU4 YesY
KEGG D07307 YesY
ChEMBL CHEMBL2104153 N
Chemical data
Formula C19H21N3S
Molecular mass 323.46 g/mol
  • N#Cc2cc1N(c3c(Sc1cc2)cccc3)CC(C)CN(C)C
  • InChI=1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3 YesY
  • Key:SLFGIOIONGJGRT-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class which was introduced by Theraplix in France in 1972 and later in Portugal as well.[1][2][3][4] It is used for the treatment of schizophrenia and, especially, for psychosis-associated anxiety, due to its unique anxiolytic efficacy.[5][6]

Cyamemazine differs from other phenothiazine neuroleptics in that aside from the usual profile of dopamine, α1-adrenergic, H1, and mACh receptor antagonism,[7] it additionally produces potent blockade of several serotonin receptors, including 5-HT2A, 5-HT2C, and 5-HT7.[7][8][9][10] These actions have been implicated in cyamemazine's anxiolytic effects (5-HT2C) and lack of extrapyramidal side effects (5-HT2A),[7][8] and despite being classified as a typical, it actually behaves like an atypical antipsychotic.[11]

See also

References

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